Pharmaceutical Intermediates Pain Killers Paracetamol/ Acetaminophen/ Panadol 103-90-2

Pharmaceutical Intermediates Pain Killers Paracetamol/ Acetaminophen/ Panadol 103-90-2

Paracetamol is well absorbed in the gastrointestinal tract. Oral bioavailability is dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity; and therefore, bioavailability is increased. Rectal administration of paracetamol is also feasible. In diesem Fall, bioavailability is inconsistent and in overall reduced, due to incomplete dissolution of the suppository in the rectum. The absorption rate through this route of administration is elongated.

Paracetamol is distributed throughout the body fluids in a homogeneous way. The analgesic activity is attributable to the small fraction that penetrates into the brain. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%. In case of intoxication, this proportion may increase to up to 50%.

Paracetamol is essentially metabolized in the liver by conjugation with glucuronic acid (55%) and sulfuric acid (35%). Hepatotoxic metabolites are produced in small amounts by the cytochrome P450 (isoenzyme CYP2E1). In the therapeutic plasma concentration range, this metabolite is detoxified by conjugation with glutathione. In case of intoxication the amount of this toxic metabolite increases and outweighs the amount of available glutathion, which can lead to hepatic failure and renal tubular necrosis.

Paracetamol/ Acetaminophen/ Panadol Verwendung:

Antipyretische Analgetika, internationales, nicht proprietäres Medikament namens Paracetamol. Es ist das am häufigsten verwendete nicht entzündungshemmende fiebersenkende Analgetikum, fiebersenkende Wirkung ähnlich wie Aspirin, Die analgetische Wirkung ist schwach, Keine antirheumatische oder entzündungshemmende Wirkung,

Besonders geeignet für Carbonsäure-Medikamente, die Patienten nicht verwenden können. Gegen Erkältung, Zahnschmerzembolie. Acetaminophen ist ein Zwischenprodukt in der organischen Synthese, photographic chemicals.Used as antipyretic, Analgetikum, antirheumatische Medikamente.