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Ethinylestradiol / Ethynyl Estradiol

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Raw Steroid Powder Ethinylestradiol / Ethynyl Estradiol CAS 57-63-6 For Treatment Of Female Hypogonadism

 

 

Quick Deails

Product name Ethinylestradiol
CAS No. 57-63-6
Chemical Name NOVESTROL; NEO-ESTRONE; ETHYNYLESTRADIOL
Molecular Weight 296.41
Molecular Formula C20H24O2
Purity 99%
Usage A synthetic steroid with high oral estrogenic potency
Standard USP28
Appearance White or almost white crystalline powder
Package 1kg/aluminium foil bag or as your request
Payment T/T,Western Union,Bitcoin,Money Gram,ect.
Delivery After payment 3-7days

 

 

Abstract

 

Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme.

Ethinyl Estradiol and its metabolites are excreted with the bile. Due to the effect of entero hepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes.

In circulation Ethinyl Estradiol is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.

Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the Ethinyl Estradiol dose from as high as 100 μg to as low as 10 μg in

 

 

Specification
Item Specification Results
Appearance White to creamy white, odorless, crystalline powder. white crystalline powder
Solubility Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides. Conforms
Identification A:IR B:UV Conforms
Specific optical rotation -28°~ -29.5° -28.3°
Melting range 180~186ºC 182.5~185.3ºC
Loss on drying ≤1.0% 0.45%
Residual Solvents Acetone≤0.5% 0.08%
Assay 97.0~102.0% (on the dried basis) 99.43%
Particle Size 90% ≤10μ Conforms
Conclusion The product complies with specification in USP34

 

 

Application

As Estinyl, EE2 was formerly used for hormone replacement therapy in menopause and the treatment of femalehypogonadism, loss of menstruation, dysmenorrhea, acne, prostate cancer, and breast cancer. However, in more recent times, EE2 is mainly used in COCs. In contraception, due to concerns of unopposed estrogen action and the possible increased risk of endometrial cancer that accompanies this, EE2 is formulated in combination with progestins. EE2 is little used in menopausal hormone replacement therapy.

EE2 has been used at very high dosages (1-2 mg/day) in the treatment of prostate cancer.

 

Raw Steroid Powder Ethinylestradiol / Ethynyl Estradiol 57-63-6 For Treatment Of Female Hypogonadism

 

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Estradiol enantate HEXESTROL Bentelan
Ethynyl estradiol Progesterone Betamethasone
Algestone acetophenide Medroxyprogesterone acetate Clobetasol propionate
Ethisterone Norethindrone Halobetasol propionate
19-Norethindrone acetate Mifepristone Deflazacort
Norethisterone Enanthate Methyldienedione Tazarotene
Ethynodiol diacetate Eplerenone Ecdysone
Pregnenolone acetate Levonorgestrel Desloratadine
Lynestrenol Allylestrenol Prednisolone phosphate sodium
Chlormadinone acetate Dienogestrel Fluorometholone Acetate
Cyproterone acetate Drospirenone Dexamethasone Acetate
Megestrol acetate Pregnenolone Dexamethasone Sodium Phosphate
Melengestrol acetate Mometasone furoate Dexamethasone palmitate
Betamethasone acetate Beclomethasone dipropionate Fluocinolone acetonide
Betamethasone Dipropionate Betamethasone 17-valerate

 

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