Zhongshan Latterson Biotechnology Co., Ltd.

Megestrol Acetate

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Prohormone, Raw steroids powder
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Prohormone Raw steroid Powder Megestrol Acetate CAS 595-33-5 For Female Muscle Growth

 

 

Abstract

Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.

Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.

 

 

Specification

Test Items Specification Test Results
Appearance White to creamy white crystalline powder White crystalline powder
Identification IR Complies
Completeness of solution Meets the requirements.500mg being Complies
dissolved in 10ml of acetone
Insoluble in water, sparingly soluble in
alcohol. Slightly soluble in ether and in
fixed oils, soluble in acetone; very soluble
Complies
Solubility
Melting range 213ºC~220ºC 217ºC
Specific optical rotation +8.8°~ +12.0° +11.6°
Water ≤0.5% 0.1%
Residue roration ≤0.2% 0.06
Heavy metals ≤0.002% Complies
Assay 97.0%~103.0% 99.6%
Residual solvents Methanol≤1000ppm 74ppm
Ethanol≤1000ppm 39ppm
Methylene chloride≤500ppm 28ppm
ND
Benzene≤2ppm ND

 

 

Usage

1. Megestrol is used mainly to treat breast cancer. It is also sometimes used to treat endometrial cancer and prostate cancer.

2. Megestrol can be used to treat metastatic or recurrent breast cancerafter tamoxifen treatment. It can also be used when tamoxifen is not effective.

3. Megestrol can be used as an appetite stimulant for people experiencing loss of appetite and weight loss because of advanced cancer.

4. A synthetic progestational agent, commonly used for estrus control in dogs and cats and also in the treatment of behavioral abnormalities and a variety of inflammatory skin diseases, including miliary dermatitis and eosinophilic granuloma.

5. Suppress growth of progestin-sensitive breast and endometrial tumors by inhibiting pituitary and adrenal function.

Megestrol acetate in liquid suspension form is approved to treat the following conditions in patients with AIDS:

Anorexia (loss of appetite).

Cachexia (weakness and loss of weight and muscle).
Megestrol acetate is also being studied in the treatment of anorexia and cachexia incancer and other conditions.

 

 

 

How It Works

Megestrol is a man-made progestin similar to the hormone progesterone. Experts do not completely understand how megestrol works. But most believe that it interferes with receptors that help breast cancer grow and spread.

Why It Is Used

Megestrol can be used to treat metastatic or recurrent breast cancer after tamoxifen treatment. It can also be used when tamoxifen is not effective.

Megestrol is used mainly to treat breast cancer. It is also sometimes used to treat endometrial cancer and prostate cancer.

Megestrol can be used as an appetite stimulant for people experiencing loss of appetite and weight loss because of advanced cancer.

 

 

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