Ketoprofeno Materias primas farmacéuticas CAS 22071-15-4

Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4

Ketoprofeno Información básica:
Nombre: ketoprofeno
CASO: 22071-15-4
MF: C16H14O3
MW: 254.28
Estándar: USP
Pureza: Grado farmacéutico 99%
Apariencia: polvo blanco
propiedades químicas: Sólido cristalino blanco
Embalaje: 25KG / tambor de fibra
Utiliza ketoprofeno, un derivado del ácido propiónico, es un agente antiinflamatorio no esteroideo (NSAIA) con propiedades analgésicas y antipiréticas.
Usos antiinflamatorios; analgésico

Pharmacodynamics

Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) con propiedades analgésicas y antipiréticas. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoartritis, dismenorrea, and alleviate moderate pain.

Mecanismo de acción

The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, g/kg en ratas, and subsequent heat dissipation.

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