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Pharmaceutical Raw Materials Ketoprofen for Treatment Rheumatoid Arthritis 22071-15-4

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Abstract

CAS:22071-15-4
MF:C16H14O3
MW:254.28
EINECS:244-759-8
Melting point:93-96°C
Boiling point:357.5°C (rough estimate)
Density 1.1565 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. 0-6°C
solubility Slightly soluble in chloroform and methanol.
Merck 14,5305
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N

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Pharmaceutical Raw Materials Ketoprofen for Treatment Rheumatoid Arthritis 22071-15-4

Abstract

CAS:22071-15-4
MF:C16H14O3
MW:254.28
EINECS:244-759-8
Melting point:93-96°C
Boiling point:357.5°C (rough estimate)
Density 1.1565 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. 0-6°C
solubility Slightly soluble in chloroform and methanol.
Merck 14,5305
InChIKeyDKYWVDODHFEZIM-UHFFFAOYSA-N

Description

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAIA) with analgesic and antipyretic properties. The pharmacological action of ketoprofen is similar to other non-steroidal anti-inflammatory drugs, which inhibit the synthesis of prostaglandins. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.The anti-inflammatory effect of ketoprofen is thought to be due to inhibition of cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in a decrease in the level of prostaglandins, which can relieve pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor, and inhibition of COX-1 is thought to cause side effects such as gastrointestinal disorders and ulcers. Ketoprofen is believed to have anti-bradykinase activity and lysosomal membrane stabilization. The antipyretic effect may be due to the action on the hypothalamus, resulting in increased peripheral blood flow,vasodilation and subsequent heat dissipation.

Applicant

Anti-inflammatory or anti-inflammatory refers to a substance or therapeutic property that reduces inflammation or swelling. Anti-inflammatory drugs account for about half of analgesics, relieving pain by relieving inflammation, rather than opioids, which affect the central nervous system.
Non-steroidal anti-inflammatory drugs
Non-steroidal anti-inflammatory drugs (NSAIDs) relieve pain by combating cyclooxygenase (COX) enzymes. The COX enzyme separately synthesizes prostaglandins and produces inflammation. In general, non-steroidal anti-inflammatory drugs can prevent prostaglandin synthesis, reduce or eliminate pain.
Some common examples of non-steroidal anti-inflammatory drugs are aspirin, ibuprofen and naproxen. The new specific COX-inhibitors are not classified with traditional non-steroidal anti-inflammatory drugs, although they may have the same mode of action

COA
ITEM SPECIFICATIONS RESULTS
IDENTIFICATION .IR: THE INFRARED SPECTRUM OF THE SAMPLE

CORRESPONDS TO THE STANDARD SPECTRUM.

CONFORMS
APPEARANCE LIGHT YELLOW TO YELLOW LIQUID CONFORMS
RESIDUE ON IGNITION ≤0.1% 0.08%
WATER ≤0.2% 0.13%
TOTAL IMPURITY ≤1.0% 0.15%
PURITY ≥99.0% 99.85%
CONCLUSION THE RESULTS CONFORMS WITH ENTERPRISE STANDARDS

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