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Anti-Fibrosis Piresupa Sarm Powder Pirfenidone S-7701 AMR-69 CAS 53179-13-8

CATÉGORIE ET ​​ÉTIQUETTES:
APIS
Attestation: ISO 9001, USP,BPF
Numéro de modèle: 53179-13-8
Quantité minimum d'achat: négociation
Heure de livraison: 3-5 jours de travail
Modalités de paiement: Western union, MoneyGram, T/T, bitcoins
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  • Caractéristiques

Anti-Fibrosis Piresupa Sarm Powder Pirfenidone S-7701 AMR-69 CAS 53179-13-8

La description:

Pirfénidone (AUBERGE, BAN) is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. It is a drug developed by several companies worldwide, including InterMune Inc. (now part of Roche), Shionogi Ltd., and GNI Group Ltd. Dans 2008, it was first approved in Japan for the treatment of IPF after clinical trials, under the trade name of Pirespa by Shionogi & Co. In October 2010, the Indian Company Cipla launched it as Pirfenex. Dans 2011, it was approved for use in Europe for IPF; it was approved in Canada in 2012 ; and was approved in the United States in October 2014 under the same name. In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013 under the trade name of Etuary. Dans 2014 it was approved in Mexico under the name KitosCell LP, indicated for pulmonary fibrosis and liver fibrosis.There is also a topical form created for the treatment of abnormal wound healing processes.

spécification
ANALYTICAL ITEMS SPECIFICATION ANALYTICAL RESULTS
Apparence White to Off-White Powder Off-White powder
Substances apparentées A single impurity≤0.5% 0.13%
Total impurities≤1.0% 0.37%
Perte au séchage 0,5 % 0.09%
Essai >99.0% 99.2%
Conclusion Confirms to Enterprise Standard

Application

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – bêta – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – bêta – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis . Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfénidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Related SARMs:
Non Nom n ° CAS
1 LGD-4033 1165910-22-4
2 MK-2866 1202044-20-9
3 MK-677 1132656-73-5
4 GW-501516 317318-70-0
5 AICAR 2627-69-2
6 SR9009 1379686-30-2
7 RAD140 1182367-47-0
8 Andarine(S4) 401900-40-1

 

 

Pirfenidone Adverse effects

1. Gastrointestinal
Pirfenidone is frequently associated with gastrointestinal side effects such as dyspepsia, nausea, gastritis, gastroesophageal reflux disease (GERD) and vomiting.To reduce the severity of these reactions, pirfenidone is to be taken after meals.

2. Skin
Pirfenidone is known to cause photosensitivity reactions, rash, pruritus and dry skin. Patients are usually advised to avoid direct exposure to sunlight, including sun lamps, and to use protective clothing and sunscreening agents. Continuing photosensitivity reactions are usually managed by dose adjustment and temporary discontinuation of treatment if required, along with local symptomatic treatment.

3. Hepatic dysfunction
Pirfenidone can increase hepatic enzyme levels, especially those of aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyl transpeptidase (GGT); periodic monitoring of hepatic enzyme levels is required during therapy: once before the initiation of therapy, monthly monitoring until 6 months after initiation of therapy, et 3 monthly thereafter. Extra precaution is required while prescribing the drug in patients with hepatic impairment and in patients who are concomitantly taking a CYP1A2 inhibitor. The drug is contraindicated in patients who have severe hepatic impairment.

4. Dizziness and fatigue
Dizziness and fatigue have been reported in patients undergoing pirfenidone treatment. Dizziness typically resolves, although patients should know how they react to pirfenidone before undertaking activities that need mental alertness or coordination. If severe, dose adjustment or treatment discontinuation may be required.

5. Perte de poids
Weight loss has been reported in patients treated with pirfenidone. Doctors should monitor patientsweight and encourage increased calorific intake if necessary.

 

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