NSI-189

MF:C22H30N4O

MW: 366.4998

EINECS:-0

Synonymes:NSI-189;[2-[(3-Methylbutyl)aminé]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;[2-[(3-Methylbutyl)aminé]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)aminé]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl];(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl],NSI-189

Background

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro .

In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer’s disease, and major depressive disorder (MDD).

Method of Action

Although it has been demonstrated in rats and chimps, the suggestion that having too small of a hippocampus causes depression and other diseases in humans is still technically just a theory. NSI-189 increases hippocampal volume in adult mice by 20%, a region of the brain that is one of the first to suffer damage resulting in memory loss, disorientation, encephalitis, and hypoxia from disease’s such as Alzheimer’s .

Avantages

Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 .

The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression – Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .

How NSI-189 works

This drug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance. Aside from increasing hippocampal volume, the drug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.

Dosage and Suggestion

Studies conducted to evaluate effects of NSI-189 revealed that 40 à 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded. Generally, NSI-189 is well tolerated and safe for human use.

Our Commitment

1.Assurance qualité
Avec nos années d'expérience, technologie de pointe et recherche continue, our quality is to fully meet the needs of the market to meet the requirements ofcustomers, de nombreux clients utilisent nos produits, we believe that the product is very good.Whether it is a powder, ou liquide, Oui, nous savons tous, notre liquide mieux.

2.Transport sécurisé
Notre mode de transport est pris en fonction de la situation de chaque pays est un transport différent, tandis que notre emballage, selon la dernière situation douanière,constamment mis à jour, amélioré nos emballages, nous vous garantissons que vous le recevrez dans 3-5 à votre produit.

3.La diversité des produits
Nos produits sont des poudres et des liquides, Oui, frères, l'effet du liquide est très bon, mais beaucoup de gens n'utilisent pas de liquide, donc tu as beaucoup de chance, vous achetez notre poudre, nous pouvons vous dire la méthode de fabrication du liquide Si vous achetez un liquide, we will tell you how to filter.We absolutely guarantee that you can very safely

4.Service de haute qualité

Our goods packing will not contain any hormone information and can be sent outfrom different areas of china.At present,le taux de dédouanement des marchandises que nous envoyons aux états-unis et en Europe est 99%, Quant au Canada, Le Brésil d'une zone de taux de fermeture de boucle assez élevée, we also have a new way to get through the customs.We also have completely re-send policy to some areas.

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