Antihistamines Pharmaceutical Raw Material Loratadine Powder CAS: 79794-75-5

Supériorité

Zhongshan Latterson Biotechnology Co., Ltd., est une entreprise pharmaceutique complète, qui s'est spécialisé dans la technologie biopharmaceutique 7 années. L'entreprise est située dans la ville de Zhongshan, Province de Guangdong , Chine.
Notre usine couvre une superficie de 33500 mètres carrés, avec un environnement propre et une belle mise en page. Il existe plusieurs ateliers de grande ou moyenne taille et un centre d'assurance qualité et de recherche avec un équipement de pointe. Maintenant, nos principaux produits sont des séries de stéroïdes anabolisants, Série peptidique, Série d'anesthésie locale. Nos produits atteignent le niveau avancé du marché intérieur, dont beaucoup atteignent la norme internationale, les certificats contiennent: KASCHER , ISO 9001:2008 , BPF , SGS.

Nom du produit: Loratadine
Synonymes: LORATADINE;LORATADINE-D5;LORATIDINE;CLARATYNE;CLARITIN;éthyle 4-(8-chloro-

5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate;4(8

-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-

PIPERIDINECARBOXYLATE;4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-

YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
CAS: 79794-75-5
MF: C22H23ClN2O2
MW: 382.88
EINECS: 1308068-626-2
catégories de produits: Active Pharmaceutical Ingredients;Intermédiaires & Fine

Chemicals;Médicaments;API’s;Histamine receptor;Amines;Hétérocycles;Pharmaceutical

intermediate;Other APIsMelting point 134-136°C
RTECS TM6129200
température de stockage. 2-8°C
solubility DMSO: 26 mg/mL, soluble
form powder
color white
Water Solubility It is soluble in DMSO (50 mg/ml), éthanol (77 mg/ml at 25°C),water (<1 mg/ml at 25°C), chloroforme, and methanol.
Merck 14,5578
Stabilité: Stable, but may be heat sensitive – refrigerate. Incompatible with strongoxidizing agents.

Loratadine Usage And Synthesis

Abstract Loratadine, sold under the brand name Claritin among others.Loratadine(Claritin) is a long-acting, non-sedating antihistamine that is used for the treatment of allergies. Histamine is a chemical that causes many of the signs and symptoms of an allergy. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that we associate with allergy, including welts, itching, and tissue swelling. Loratadine(Claritin) blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine.

Antiallergic Loratadine is a common antiallergic medication, which is a second generation long-acting tricyclic antihistamine, rapid onset of action is strong, does not contain hormones, absorbed by the body metabolism with more active desloratadine, inhibiting histamine H1 receptor by competitively inhibit histamine-induced allergic symptoms, with no obvious anticholinergic and central inhibition. It is used for the relief of clinical symptoms of allergic rhinitis related, such as sneezing, runny nose and nasal itching, eye itching and burning. It is also used to relieve symptoms of chronic urticaria and other allergic skin diseases.

Drug Interactions Inhibition of hepatic drug-metabolizing enzyme function drugs can slow the metabolism of the product, such as itraconazole, ketoconazole, Daily with 400 mg ketoconazole suit, can make the product and its active metabolite to carboxyethyl loratadine increased plasma concentrations, but it was not observed in the changes of electrocardiogram (ECG). It can also inhibit the metabolism of loratadine when used with macrolides, cimetidine, theophylline and other drugs together.

Application

Antihistamines, peripheral nerves are highly selective H1-receptor, the role of strong,long time. For allergic arthritis, allergic rhinitis.National second-class anti-allergy drugs, for the relief of seasonal allergic rhinitisnasal and non-nasal symptoms and relieve chronic urticaria.Side effects Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the second-generation antihistamine family ofmedication.Preparation Compound (I) (0.05mo1) was dissolved in toluene (450m1), dropwise additionof ethyl chloroformate (0.15mo1). Canada finished in the sauna heating 2h, and then stirred at room temperature overnight. Added 800ml water. The benzene layer was separated, washed with water, and dried. Decompression concentrated oil, with petroleum ether afterimpregnation with acetonitrile, recrystallization, the yield of loratadine, 64%.Chemical Properties White Crystalline Solid
Uses antinflammatory, analgesic, antipyretic
Uses Anti-histamine
Uses A nonsedating-type histamine H1-receptor
Biological Activity Peripheral histamine H 1 receptor antagonist (K i = 35 nM); devoid of central effects. Orally active antiallergic agent.

Notre service

1.100% La politique de réexpédition est notre base commerciale. 100% de réexpédition immédiatement si votre colis reste en douane pendant 4 jours et n'est pas mis à jour.
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4.Nous avons un emballage spécial ,Il peut être facilement passé à la douane. Il sera plus sûr.
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