Zhongshan Latterson Biotechnology Co., Ltd.

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Antihistamines Pharmaceutical Raw Material Loratadine Powder CAS: 79794-75-5

Other Hot-Sale Products (Raw Powder)
Model Number : 79794-75-5
Certification : ISO9001 , GMP , KOSHER , SGS
Place of Origin : China
MOQ : 10g
Price : Negotiable ( Discounts For Big Order )
Payment Terms : Western Union , Moneygram , Bitcoin , Bank Transfer
Supply Ability : 100kg per month
Delivery Time : 7 work days
Packaging Details : Stealth And Discreet Packaging
Product Name : Loratadine
CAS : 79794-75-5
MF : C22H23ClN2O2
MW : 382.88
EINECS : 1308068-626-2
Appearance : White Powder
  • Specifications

Antihistamines Pharmaceutical Raw Material Loratadine Powder CAS: 79794-75-5


Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

Product Name: Loratadine




CAS: 79794-75-5
MF: C22H23ClN2O2
MW: 382.88
EINECS: 1308068-626-2
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine

Chemicals;Pharmaceuticals;API’s;Histamine receptor;Amines;Heterocycles;Pharmaceutical

intermediate;Other APIsMelting point 134-136°C
RTECS TM6129200
storage temp. 2-8°C
solubility DMSO: 26 mg/mL, soluble
form powder
color white
Water Solubility It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C),water (<1 mg/ml at 25°C), chloroform, and methanol.
Merck 14,5578
Stability: Stable, but may be heat sensitive – refrigerate. Incompatible with strongoxidizing agents.

Loratadine Usage And Synthesis

Abstract Loratadine, sold under the brand name Claritin among others.Loratadine(Claritin) is a long-acting, non-sedating antihistamine that is used for the treatment of allergies. Histamine is a chemical that causes many of the signs and symptoms of an allergy. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that we associate with allergy, including welts, itching, and tissue swelling. Loratadine(Claritin) blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine.

Antiallergic Loratadine is a common antiallergic medication, which is a second generation long-acting tricyclic antihistamine, rapid onset of action is strong, does not contain hormones, absorbed by the body metabolism with more active desloratadine, inhibiting histamine H1 receptor by competitively inhibit histamine-induced allergic symptoms, with no obvious anticholinergic and central inhibition. It is used for the relief of clinical symptoms of allergic rhinitis related, such as sneezing, runny nose and nasal itching, eye itching and burning. It is also used to relieve symptoms of chronic urticaria and other allergic skin diseases.

Drug Interactions Inhibition of hepatic drug-metabolizing enzyme function drugs can slow the metabolism of the product, such as itraconazole, ketoconazole, Daily with 400 mg ketoconazole suit, can make the product and its active metabolite to carboxyethyl loratadine increased plasma concentrations, but it was not observed in the changes of electrocardiogram (ECG). It can also inhibit the metabolism of loratadine when used with macrolides, cimetidine, theophylline and other drugs together.


Antihistamines, peripheral nerves are highly selective H1-receptor, the role of strong,long time. For allergic arthritis, allergic rhinitis.National second-class anti-allergy drugs, for the relief of seasonal allergic rhinitisnasal and non-nasal symptoms and relieve chronic urticaria.Side effects Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the second-generation antihistamine family ofmedication.Preparation Compound (I) (0.05mo1) was dissolved in toluene (450m1), dropwise additionof ethyl chloroformate (0.15mo1). Canada finished in the sauna heating 2h, and then stirred at room temperature overnight. Added 800ml water. The benzene layer was separated, washed with water, and dried. Decompression concentrated oil, with petroleum ether afterimpregnation with acetonitrile, recrystallization, the yield of loratadine, 64%.Chemical Properties White Crystalline Solid
Uses antinflammatory, analgesic, antipyretic
Uses Anti-histamine
Uses A nonsedating-type histamine H1-receptor
Biological Activity Peripheral histamine H 1 receptor antagonist (K i = 35 nM); devoid of central effects. Orally active antiallergic agent.

Our service

1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
2.Total refund for 15 days of dissatisfaction with quality.
3.We can provide free samples.
4.We have a special packing ,It can be easily passed through the customs.It will be more safe.
5.Our company have a long term cooperate with DHL.EMS.Fedex and so on .It can be sent to your hand more quickly. Parcel photo should be offered within 12hours after receiving your steroid payment.
6.If you have a chance to come to China. I can show you our lab.
7.Our company has WU, MG, TT, and Bitcoin payment ways in advance.You can pay 95% for the peptides cost at first for order, the rest can offer us in your next order;

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