Anestésico local Anestésico Anodyne CAS 136-47-0 clorhidrato de tetracaína / clorhidrato de tetracaína
clorhidrato de tetracaína
CASO:136-47-0
MF:C15H25ClN2O2
MW:300.82
EINECS:205-248-5
Sinónimos:L AND OCAIN HYDROCHLORIDE;INTERCAIN HYDROCHLORIDE;MEETHOBALM HYDROCHLORIDE;2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER HYDROCHLORIDE;4-[BUTYLAMINO]BENZOIC ACID-2-[DIMETHYLAMINO]ETHYL ESTER HYDROCHLORIDE;4-BUTYLAMINOBENZOIC ACID DIMETHYLAMINOETHYL ESTER HCL
Propiedades
Punto de fusion:149° C
temperatura de almacenamiento. Refrigerator
solubility alcohol: solublesoluble 40 parts of solvent
pka8.39(at 25℃)
Water Solubility Soluble in water at 50mg/ml
Merck 14,9188
InChIKeyPPWHTZKZQNXVAE-UHFFFAOYSA-N
Descripción
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Especificación
| Elementos de prueba |
Especificación |
Resultados de la prueba |
| Apariencia |
Fine, white, crystalline, odorless powder |
confirm |
| Identificación |
ABC in Pass |
confirm |
| Solubilidad |
Muy soluble en agua, soluble in Alcohol; insoluble in Ether and Benzene |
confirm |
| USP Reference standards |
USP Tetracaine Hydrochloride RS. USP Endotoxin RS. |
confirm |
| Punto de fusion |
145~150 degree |
146.0~147.5
degree |
| Chromatographic purity |
In Pass |
confirm |
| Related substance |
Not more than the reference solution 0.05% |
confirm |
| Metales pesados |
≤10 ppm |
confirm |
| PH |
4.5-6.5 |
5.8 |
| Residuos en ignición |
≤0.10% |
0.05% |
| Loss on Drying |
≤ 0.5% |
0.19% |
| Ensayo |
98.0 -101.0% |
100.1% |
| Conclusión |
Confirms USP 32 |
Uso
Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum and Tetracaine hydrochloride is used for spinal anesthesia.
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