Prl-8-53 for Dietary Supplement Nootropics Supplement Powder Prl-8-53 HCl 51352-87-5
Nom:PRL-8-53
Nom chimique:Méthyle 3-(2-(benzyle(méthyle)aminé)éthyle)benzoate
Synonymes:PRL-8053;PRL-8-53;Méthyle 3-(2-(benzyle(Méthyle)aMino)éthyle)benzoate hydrochloride;3-(2-Benzyle(méthyle)aminoéthyle)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)éthyle]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Méthyle(phenylMethyl)aMino)éthyle)-, Methyl ester, chlorhydrate
CAS 51352-87-5
MF:C18H22ClNO2
MW 319.82578
Dosage:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects
Prl-8-53 HCl Abstract
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (PRL-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
Prl-8-53 HCl Description
PRL-8-53 (nom chimique méthyle 3-(2-(benzyle(méthyle)aminé)éthyle)benzoate) est un composé nootropique synthétique découvert dans 1972 et breveté en 1975 par le regretté Dr. Nicolas Hansl, neuropharmacologue à l'Université Creighton à Omaha, Nebraska. Des tests préliminaires sur les animaux ont indiqué que le composé était à la fois sûr et significativement nootropique., stimuler l’apprentissage de l’évitement chez les rongeurs sans effets indésirables. Mais le véritable intérêt pour le PRL-8-53 a été suscité par un 1978 étude sur des volontaires humains, qui a montré qu'une dose unique du composé pouvait améliorer les scores de rétention de mots de plus de 200%.
HOW Prl-8-53 HCl WORKS
PRL-8-53’s exact mechanisms of action are not well understood, but it is generally believed to regulate the brain’s production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain’s response to acetylcholine.
Though Hansl’s research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53’s effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
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