| Plant Extract |
La sinefrina es un tipo de sustancia activa biológica., extraído principalmente de la naranja, cáscara de mandarina, cáscara verde y plantas rutáceas, es una medicina tradicional china y juega un papel importante como componente eficaz de frutus aurantii immaturus, tiene un corazón fuerte, aumentar la contracción del volumen sanguíneo, vasos sanguineos, alta resistencia vascular periférica total y aumenta la presión ventricular izquierda y el efecto de la presión arterial, resistencia a los golpes, y el efecto que reduce el peso, but because the Synephrine has the similar structure to that of jute alkali has excited central nervous, Los posibles efectos secundarios de las enfermedades cardiovasculares., En los últimos años su uso está limitado a los Estados Unidos., Canadá y otros países.
Cifra 1 the extract of frutus aurantii immaturus Synephrine |
| Pharmacological function |
The pharmacological effects of Synephrine is stimulant, mainly acts on the adrenaline receptor, the heart also have certain excitation; Puede encoger los vasos sanguíneos presión arterial elevada expansión de la tráquea y los bronquios; Also has a certain of losing weight and the antidepressant effects, mainly used in the treatment of bronchial asthma clinical shock and hypotension collapse and orthostatic hypotension dyspepsia not gastroptosis etc. Synephrine is a kind of pure natural stimulant, without any side effects and positive reactions, and has been widely used in medicine, food and beverage and other industries. |
| Separation and extraction methods |
En el presente, the extraction and separation method of high purity Synephrine is not mature, and the commonly used method is mainly cationic bunch of ester exchange method and hydrochloric acid percolation method, etc.. Market demands for acid-insoluble ash extract hesperidin contain the Synephrine and is huge, so it is necessary to establish a comprehensive process route to utilize the frutus aurantii immaturus, extraction of frutus aurantii immaturus Synephrine and hesperidin. |
| Content analysis method |
With the increasing market demand of Synephrine, Synephrine is more valuable. Studies for detection method of the content is unceasingly thorough, the reported methods are (1) reverse high performance liquid chromatography (RP-HPLC), (2) packed column supercritical fluid chromatography (SFC), (3) the HPLC method, (4) thin layer scanning method, (5) combination with high performance liquid chromatography and thin layer chromatography scanning method, etc.. |
| HPLC method for the determination of synephrine content in hovenia dulcis of rutaceae plants |
[Test Article] rutaceae plant orange Citrus teticulata Blamco and cultivar dry and mature skin, medicinal herbs called “orange” Estanozolol semielaborado de la serie líquida de esteroides “wide” cáscara de mandarina, or lime Citrus aurantiwm L and its cultivar immature fruit, dry or sweet orange C.Sinensis Osbeck dry young fruit, medicinal herbs called orange; Orange and its dry cultivated varieties of young fruit or immature fruit peel, medicinal herbs, green husk.
1. chromatographic
Column chromatographic conditions: Micropak MCH-5 c18; Mobile phase: 0.02 mol/L phosphoric acid methanol solution and 0.2% sodium dodecyl sulfate; Column temperature: 50 ℃; Flow rate: 1 ml/min: detection wavelength 275 Nuevo Méjico.
2. the preparation of the reference substance solution
Accurate weight synephrine 4 mg, dilute with 10 Estanozolol semielaborado de la serie líquida de esteroides 0.01 mol/L HCL.
3. the preparation of sample solution
Take 1 g of fine powder sample in 50 ml taper bottle with plug, agregar 20 ml methanol, ultrasonic oscillation extraction for 15 min, stand for 4 H, filtrar, take further filtrate 5 ml in 10 ml of centrifugal pipe plug, 90 ℃ insoluble dry, cool, agregar 0.01 mol/L of hydrochloric acid and chloroform each 2 Estanozolol semielaborado de la serie líquida de esteroides, dense vibration wave, centrifugal, take supernatant on standby.
4. measurement
Precision learn each 10 ml of the sample solution and reference substance solution, inyección, according to chromatographic analysis condition.
5. Analysis results
Cifra 2 Different origin Citrus aurantium, bran fried Bitter Orange Synephrine (n = 6,%) |
| Propiedad química |
Ether hydrochloride, colorless crystalline (etanol), punto de fusion: 166 ℃-167 ℃, [a] 27 d-52. (C = 7.6 mg / ml, anhydrous methanol). In strong acid, strong alkali ion exchange resin chromatography separation easy occurred in despun role. Crystallization and melting point: 184 ℃-185 ℃; Hydrochloride crystallization, punto de fusion: 151 ℃-152 ℃, Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide. Heavy tartrate, 188 ℃-189 ℃ (partial decomposition), Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide, soluble in ether, hardly soluble in chloroform, éter. |
| Usos |
Vasopressors. Are used in shock, insuficiencia cardiaca, treatment of bronchial asthma and bottom blood pressure during surgery and anesthesia, collapse and shock body, a low blood pressure, etc.. |
| Production Method |
Rutaceae plant lime Citrus aurantium l. resultados. |
| Propiedades químicas |
Off-White to Beige Powder |
| Usos |
Un agonista del receptor α-adrenérgico, vasoconstrictor. |
| Usos |
anti-obesity |
| Usos |
A a-adrenergic receptor agonist, vasoconstrictor |
| Definición |
Chebi: A phenethylamine alkaloid that is 4-(2-aminoetilo)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. |
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