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  • Sunifiram Raw powder CAS 314728-85-3 Bodybuilding Fast and Safe Delivery

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    Other Hot-Sale Products (Raw Powder)

    Payment & Shipping Terms:

    Minimum Order Quantity: 10g
    Price: Negotiable
    Packaging Details: Camouflage
    Delivery Time: 3-7work days
    Payment Terms: MoneyGram, Western Union, T/T,bitcoin
    Supply Ability: 100kg
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    • Specifications

    Sunifiram Raw powder CAS 314728-85-3 Bodybuilding Fast and Safe Delivery

    Quick Detail:

    CAS: 314728-85-3

    MF: C14H18N2O2

    MW: 246.30492

    Appearance: White powder

    Purity: 99.32%

    Shelf life: 2 years

    Standard: In-house Standard

    Usage: For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs, Senile Dementia, Acetylcholine Release Enhancers.

    Description:

    This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.

    Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).

    This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation.Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.

    Application:

    The exact mechanism to explain how Sunifiram is able to have such a strong cognitive benefit is yet to be found, but scientist have identified some interesting models to show how some of these attributes may be better understood. One such mechanism is that of NMDA signaling which was confirmed after Sunifiram dosages were maintained for over 7 days.

    This can explain some of the NMDA-dependent Long Term Potentiation seen with Sunifiram use.Further studies have shown rodents with memory impairment (centered around the hippocampus) benefitted from Sunifiram administration, when their ability to complete training sessions was measured. Finally, Sunifiram injections were able to cause the release of acetylcholine, which was detected in the prefrontal cortex of laboratory mice.

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