Factory Sell Hot Nootropics Cognitive Enhancer Powder Aniracetam CAS 72432-10-1
Превосходство
Zhongshan Latterson Biotechnology Co., ООО, комплексное фармацевтическое предприятие, которая специализируется на биофармацевтических технологиях более 7 годы. Компания расположена в городе Чжуншань., Провинция Гуандонг , Китай.
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Абстрактный
Aniracetam is anampakine nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer’s patients, and temporarily impaired healthy subjects.
| Aniracetam Basic information |
| Levetiracetam class brain cell metabolism drugs Pharmacological effects Pharmacokinetics Adverse reactionsPrecautions Chemical Properties Application Production methods |
| наименование товара: |
Анирацетам |
| Синонимы: |
1-(4-methoxybenzoyl)-2-pyrrolidinon;1-(p-methoxybenzoyl)-2-pyrrolidinon;1-p-anisoyl-2-pyrrolidinone;draganon;sarpul;1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE;ANIRACETAM;RO 13-5057 |
| КЕЙС: |
72432-10-1 |
| MF: |
C12H13NO3 |
| МВт: |
219.24 |
| EINECS: |
|
| категории товаров: |
Glutamate;» Жидкие инъекционные стероиды;» Жидкие инъекционные стероиды;» Жидкие инъекционные стероиды & » Жидкие инъекционные стероиды;Фармацевтические препараты;Smart drug;Ноотропный |
| Мол файл: |
72432-10-1.моль |
|
|
| Aniracetam Chemical Properties |
| mp |
121-122?InChI=1/C25H36O3/c1-3-4-5-6-7-24 |
| температура хранения. |
Магазин в РТ |
| Справочник по базе данных CAS |
72432-10-1(Справочник по базе данных CAS) |
|
| Информация по технике безопасности |
| ВГК Германия |
2 |
| РТЕКС |
UY5781900 |
ProviderLanguage
|
| 1-(4-Methoxybenzoyl)-2-pyrrolidinone |
English |
| SigmaAldrich |
English |
|
| Aniracetam Usage And Synthesis |
| Levetiracetam class brain cell metabolism drugs |
Анирацетам, также известный как анирацетам, вместе с пирацетамом и нефирацетамом, принадлежат к тому же классу препаратов, метаболизируемых пирацетамом клетками головного мозга. Эти препараты могут усиливать активность фосфолипазы синаптических нейронов., увеличивают образование и транспорт АТФ в головном мозге, увеличить синтез белка и РНК, способствовать использованию мозгом аминокислот, фосфолипиды, глюкоза и кислород, повысить реакцию пациента, возбудимость и память. Анирацетам обладает более сильным эффектом, чем пирацетам., но с относительно небольшим побочным эффектом. |
| Pharmacological effects |
Анирацетам, a cyclized derivative of γ- aminobutyric acid, can improve the brain function. It can selectively exert effect on central nervous system through penetration into blood-brain barrier. It can activate the metabolism activity of brain cell and protect the nerve cells. This product can also promote the intelligence by affecting the glutamate receptor system. Кроме того, it improves skin’s resistance to hypoxia, preventing the occurrence of malfunction of learning and memory caused by a variety of chemical substances, hypercapnia, scopolamine and electrical shock. This product has no sedative or excitation effect. Animal experiments show that this product promotes the memory recovery in normal rats’ learning process. It can fight against hypoxia-induced memory recession and relieve the memory malfunction caused by certain reasons.
[Показания] It is used for the treatment of mild or moderate malfunction of learning, memory and cognition in vascular dementia and Alzheimer’s disease. It can also be used for treating memory recession after stroke, memory defect in old people and children who undergo development retardation.
The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Pharmacokinetics |
According to literature, it is rapidly absorbed after oral administration by rats. The plasma concentration reaches highest level within 20 к 40 minutes. The drug is mainly distributed in the gastrointestinal tract, kidney, химическое название и суффикс, указывающие на то, что эта форма стероида и полового гормона представляет собой тип спирта, содержащего две гидроксильные группы, brain and blood. After 24 часы, 77% к 85% is excreted out through urine, 4% from faeces. Major metabolite in urine is N-p-anisoyl-aminobutyric acid and 5-hydroxy-2-pyrrolidone.
Human: After oral administration, half-life of blood Plains drug elimination averages at 20 к 30 minutes. Plasma concentration becomes undetectable after two hours. |
| Adverse reactions |
This product has fewer adverse reactions, occasionally dry mouth, anorexia, constipation, головокружение, and drowsiness. They disappear after stopping taking the drug. |
| Precautions |
1. Adjust the dose for patients of liver dysfunction.
2. It can deteriorate the symptoms of Huntington’s chorea.
3. Patients who is allergic to this drug or other pyrrolidone-class drugs are not allowed.
4. Safety range: 0.3 ~ 1.8g / г. |
| Химические свойства |
Crystallization from ethanol, m.p. 12l ~ 122 ° C. Acute toxicity LD50 for rat, mouse (мг / кг): 4500,> 5000 oral. |
| заявка |
1. Piracetam derivative, a improvement agent for γ-lactam brain function. Selectively exert effect on the brain system, promote and enhance memory function. Compared with Piracetam, it has a stronger effect, faster onset of action, and lower toxicity. Used for improving brain function, especially treating the behavioral and mental disorders for sequela patients of senile dementia, cerebrovascular disease.
2. It is a γ-lactam-class agent of improving brain function. It can exert on the brain tissue through penetrating the blood-brain barrier, and improve brain function and memory. |
| Production methods |
Method 1: Reflux the reaction mixture of 2- pyrrolidone and methoxy benzoyl chloride at 0~10 °C in ether and in the presence of triethylamine for three hours to get the Aniracetam.
Method 2: Perform the reaction between p-methoxy benzoic acid and thionyl chloride to get the methoxy benzoyl chloride (yield 90%). Then perform the reaction between methoxybenzoyl chloride and 4-aminobutyric acid in an aqueous solution of sodium hydroxide and in the presence of benzyl triethyl ammonium salt (of TEBA) to get 4- (4-methoxybenzoyl) amino butyric acid (yield 69.4%). Then have cyclization reaction in the presence of toluene and thionyl chloride to get aniracetam, yield 80.4%, mp 118 ~ 120 ° C.
Method 3: Methoxybenzoic acid is chloridized as post-methoxy benzoyl chloride first. Then it is reacted together with Sodium 2-pyrrolidone in tetrahydrofuran and 4-dimethylaminopyridine (DMAP) to obtain the aniracetam yield 76.2% (Take account of p-methoxy benzoyl chloride), the melting point of 118 ~ 119 ° C.
Method 4: 2-pyrrolidone was refluxed 1 hour in toluene containing sodium methoxide first. Then methanol was totally evaporated. Add TEBA at 10 ° C, Titrate a toluene solution of p-anisoyl chloride and stir them at room temperature for 0.5h. Then stirred at 50 °C for 6h to obtain the aniracetam of 85% yield (take account of 2-pyrrolidone), температура плавления 120 ~ 121 ° C.
Method 5: 2-pyrrolidinone and triethylamine is mixed at 0 ~ 10 °C first. Then perform titration of chlorotrimethylsilane for 2 h reaction at room temperature. Add the dioxane solution of Methoxybenzoyl chloride and stir 2h at 40 °C to obtain aniracetam, yield 65%. |
| Химические свойства |
Кристаллическое твердое вещество |
| использование |
cognitive enhancer |
| использование |
Cognition enhancer related to Piracetam. Ноотропный. |
| Биологическая активность |
Ноотропный, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration. |
|
| Aniracetam Preparation Products And Raw materials |
| Raw materials |
Thionyl chloride–>1,4-Dioxane–>4-Dimethylaminopyridine–>Chlorotrimethylsilane–>4-Aminobutyric acid–>2-Пирролидинон–>Anisic acid–>4-Methoxybenzoyl chloride |
Приложения
Aniracetam are related to improved mental performance. This includes an increase in memory and possibly even enhanced learning capacity. This may actually occur differently in each person; Some will see strong effects and begin remembering everything while others may just simply beginremembering small and subtle details.
Aniracetam is also considered be very helpful as a focusing agent. Many users note that their attention.Span is increased as well as being able to focus and concentrate much more easily. This also serves to improve mental fluidity, making even simple, routine tasks such as reading and writing (and holding conversations) seem to flow much more easily, without expending as much effort as before using aniracetam Supplements.
Improved Memory
Increased Learning Ability
Improved Cognitive Processing
Heightened Reflexes
Heightened Perception
Reduced Anxiety
Reduced Depression
If you suffer from a medical condition, do not use Aniracetam as a primary therapy. It may be used in conjunction with other therapies however it is always recommended to consult a licensed medical professional prior to administration. Limited data about side effects and interactions have been recorded and safety should be evaluated by a doctor before on or off-label usage.
Приложения
Aniracetam are related to improved mental performance. This includes an increase in memory and possibly even enhanced learning capacity. This may actually occur differently in each person; Some will see strong effects and begin remembering everything while others may just simply beginremembering small and subtle details.
Aniracetam is also considered be very helpful as a focusing agent. Many users note that their attention.Span is increased as well as being able to focus and concentrate much more easily. This also serves to improve mental fluidity, making even simple, routine tasks such as reading and writing (and holding conversations) seem to flow much more easily, without expending as much effort as before using aniracetam Supplements.
Технические характеристики
| АНАЛИТИЧЕСКИЕ ЭЛЕМЕНТЫ |
ТЕХНИЧЕСКИЕ ХАРАКТЕРИСТИКИ |
АНАЛИТИЧЕСКИЕ РЕЗУЛЬТАТЫ |
| Появление |
White Crystalline Solid |
Подтверждает |
| Депутат |
121-122 ° C |
122 ° C |
| Связанные вещества |
A single impurity≤0.5% |
0.15% |
| Total impurities≤1.0% |
0.39% |
| Убыток от высыхания |
≤0,5% |
0.14% |
| Анализ |
>99.0% |
99.6% |
| Заключение |
Подтверждает корпоративный стандарт |
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