Prl-8-53 for Dietary Supplement Nootropics Supplement Powder Prl-8-53 HCl 51352-87-5
Имя:ПРЛ-8-53
Химическое название:Метил 3-(2-(бензил(метил)амино-)этил)benzoate
Синонимы:PRL-8053;ПРЛ-8-53;Метил 3-(2-(бензил(Метил)aMino)этил)benzoate hydrochloride;3-(2-мл Масло виноградных косточек Сустанон 250мг/мл рецепт -2,5мл БА(метил)аминоэтил)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)этил]benzoic acid methyl ester hydrochloride;Бензойная кислота, 3-(2-(Метил(phenylMethyl)aMino)этил)-, Methyl ester, гидрохлорид
КЕЙС 51352-87-5
MF:C18H22ClNO2
МВт 319.82578
Дозировка:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects
Prl-8-53 HCl Abstract
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester hydrochloride (ПРЛ-8-53) on learning and on retention of verbal information in human subjects was investigated. Using the serial anticipation method under double-blind conditions it was found that PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal information was found improved to a statistically significant degree (most P values better than 0.01, some better than 0.001). No significant changes were found for either visual reaction time or motor control after drug when compared with placebo values.
Prl-8-53 HCl Description
ПРЛ-8-53 (chemical name Methyl 3-(2-(бензил(метил)амино-)этил)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%.
HOW Prl-8-53 HCl WORKS
PRL-8-53’s exact mechanisms of action are not well understood, but it is generally believed to regulate the brain’s production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain’s response to acetylcholine.
Though Hansl’s research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53’s effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
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