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Raw Material Local Anesthetic Series Pramoxine HCL For Pain Killer 637-58-1

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Abstract

CAS:637-58-1
MF:C17H28ClNO3
MW:329.86
EINECS:211-293-1
Melting point:181-183°
Hazard statements H302-H315-H319-H335
Precautionary statements P301+P312+P330-P305+P351+P338-P261
Hazard Codes Xi,Xn
Risk Statements 22-36/37/38
Safety Statements 26-36

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Raw Material Local Anesthetic Series Pramoxine HCL For Pain Killer 637-58-1

Abstract

CAS:637-58-1
MF:C17H28ClNO3
MW:329.86
EINECS:211-293-1
Melting point:181-183°
Hazard statements H302-H315-H319-H335
Precautionary statements P301+P312+P330-P305+P351+P338-P261
Hazard Codes Xi,Xn
Risk Statements 22-36/37/38
Safety Statements 26-36

Description:

Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

Application:

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.

COA:

Melting range 170~174°C 171.7~173.2°C
Loss on drying ≤1.0% 0.12%
Residue on ignition ≤0.1% 0.04%
Ethanol ≤0.5% 0.061%
Carbinol ≤0.3% 0.10%
Acetone ≤0.5% Not detected
Assay 98.0%~102.0% 99.98%
Conclusion The results conforms with USP33

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Propitocaine hydrochloride CAS: 1786-81-8
Tetracaine hydrochloride CAS: 136-47-0
Procaine hydrochloride CAS: 51-05-8
Pramoxine hydrochloride CAS: 637-58-1
Proparacaine hydrochloride CAS: 5875-06-9
Benzocaine hydrochloride CAS: 23239-88-5
Lidocaine hydrochloride CAS: 73-78-9
Articaine hydrochloride CAS: 23964-57-0
Levobupivacaine hydrochloride CAS: 27262-48-2
Ropivacaine hydrochloride CAS: 132112-35-7
Dibucaine hydrochloride CAS: 61-12-1
Bupivacaine hydrochloride CAS: 14252-80-3
Articaine CAS: 23964-58-1
Benzocaine CAS: 94-09-7
Lidocaine CAS: 137-58-6
Tetracaine CAS: 94-24-6
PROCAINE CAS: 59-46-1

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