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  • HGH Fragment 176 – 191

    • Specifications

    HGH Fragment (176-191) is a modified form of amino acids 176-191 of the HGH polypeptide.


    Investigators at Monash University discovered that the fat-reducing effects of HGH appear to be


    controlled by a small region near one end of the Hormone molecule. This region, which consists


    of amino acids 176-191, is less than 10% of the total size of the HGH molecule and appears to


    have no effect on growth or insulin resistance. It works by mimicking the way natural Hormone


    regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen


    with unmodified Hormone. Like Hormone, HGH fragment 176-191 stimulates lipolysis (the


    breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food


    materials into body fat) both in laboratory testing and in animals and humans.



    Laboratory Tests and Fat Loss:


    In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the fragment released fat


    specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat


    cells, enhanced the burning of fat. In rodents (rats and mice), fragment reduced body fat in obese


    animals but, enhanced fat burning without changing food consumption or inducing growth (as it


    does not increase IGF levels) or any other unwanted Hormone effect. Research dosages of


    500mcg of the HGH fragment 176-191 daily for 30 days did show a reduction of body fat in the


    mid abdominal area in both obese, over-weight, and average built people.


    HGH Fragment 176-191 as an Active Truncated Peptide
    HGH Fragment 176-191 is an analog of the hormone-releasing factor (GRF) which signals the


    effects of hormone. It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is


    added at the N-terminal end. This synthetically produced hormone is very common to weightlifters


    and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts


    on the reduction of excessive adipose tissues such as those in the abdominal area, increase in


    muscle mass, and enhances the lipid content of the body.



    These segments of the synthetic peptide 176-191 have been investigated for their in vivo effects


    in laboratory mice musculus. Research results have shown that 176-191 have resulted to a short-


    period increase in blood glucose and a more sustained increase in plasma insulin, together with


    other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have


    suggested that functionality of the peptide depends not only in the informational sequence but


    should also have the correct physical configuration. Also, this fragment, being a region of high


    accessibility to proteases and also rich in proline, have been demonstrated to affect the


    conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein


    by serving as the hinge for the pivoting of the two subdomains.


    This then suggest that such residue is significant in conformational changes be serving as sites


    for peripheral protein binding in some body cells.



    In another study on animal subjects, they found out that a 500mcg dosage of the said hormone


    increased the lipolytic activity in adipose tissues without having negative influence in the blood


    glucose level. Furthermore, though it behaves like a hormone , it does not causes hyperglycemia


    because it does not compete with HGH receptors. Because of such effects, researchers have


    suggested that it might be used for the elimination of excess abdominal fat which is a significant


    aspect of HIV-associated lipodystrophy.



    The ( HGH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while


    increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the


    fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its


    Hormone counterpart.









    MGF (2mg) HGH 176-191 (2mg)
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