White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

Información básica

Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations
nombre del producto: fenacetina
Sinónimos: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4′-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CASO: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Categorías de Producto: Other APIs;Organics;Amines;Aromáticos;intermedios & Productos químicos finos;Productos farmacéuticos
Archivo Mol: 62-44-2.mol
Phenacetin Structure
Phenacetin Chemical Properties
Punto de fusion 133-136 ° C(Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide)
Punto de ebullición 132 ° C / 4mmHg
Fp 2℃
temperatura de almacenamiento. 2-8° C
form powder
color White
Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide 0.076 Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Estabilidad: Stable. Incompatible with strong oxidizing agents, strong acids.

2. Descriptions:

La fenacetina es un medicamento para aliviar el dolor y reducir la fiebre., ampliamente utilizado desde su introducción en 1887 hasta que fue prohibido en los EE.UU. por la FDA en 1983. Su uso ha disminuido debido a sus efectos adversos., que incluyen un mayor riesgo de ciertos tipos de cáncer y daño renal. Se metaboliza a paracetamol., que lo reemplazó en algunos medicamentos de venta libre luego de la prohibición de la fenacetina.

3. Aplicaciones:

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an “A.P.C.” or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).

It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity.

La fenacetina ahora se usa como agente de corte para adulterar la cocaína en el Reino Unido y Canadá., owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. Es un compuesto ideal para este tipo de investigaciones..

Phenacetin COA