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Materias primas farmacéuticas Flibanserina CAS 167933-07-5 Para la mejora del sexo femenino

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Artículos para mejorar el sexo
Certificación: GMP
Número de modelo: 167933-07-5
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Materias primas farmacéuticas Flibanserina CAS 167933-07-5 Para la mejora del sexo femenino

Abstracto

CASO: 167933-07-5

MF: C20H21F3N4O

MW: 390.4

Sinónimos: metil testos terona,Bimt 17, Bimt-17-BS,Girosa;2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluorometilo)fenilo]-1-piperazinyl]ethyl]-;metil testos terona;Bimt 17;3-[2-[4-[4-(Trifluoromethyl)fenilo]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;Filbanserin;Flibanerins;1,3-Dihydro-1-[2-[4-[3-(trifluorometilo)fenilo]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one

Propiedades

temperatura de almacenamiento. 2-8° C

solubilidad DMSO: soluble10mg/mL, Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide

color blanco a beige

Abstracto

Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods).Flibanserin is in a class of medications called a serotonin receptor 1A agonist/serotonin receptor 2A antagonist. It works by changing the activity of serotonin and other natural substances in the brain.

Uso

Flibanserin comes as a tablet to take by mouth. It is usually taken once daily at bedtime. Take flibanserin at bedtime every day.

COA

Elementos Especificación
pH 3.5-4.5
Identificación 1, red to dark purple color appears
con(III)iron chloride
2, light red precipitate formed with reinecke salt TS
3, UV spectrum meet the reference
4, solution (1%) responds to the qualitative test for chloride
Punto de fusion 139-143 celcius degree
Clarity and color of solution clear and colorless
Sulfato 0.048%máximo
Metales pesados 10ppm max
As 2ppm max
Organic acid(0.1M NaOH) 0.54ml max
Pérdida por secado 0.5% máximo
Residuos en ignición 0.1%máximo
Residual organic Solvents (CG) Xylol 0.217%max
Isopropanol 0.5%max
Related substances(HPLC) Total impurity 1.5%max
Single impurity0.5%max
Free P-chloro phenoxy acetic 0.5%max
Count of bacteria bacillus 1000/1g max
Mildew 100/1g max
Microzyme 100/1g max
Ensayo(C12H16CINO3.HCl,on dry basis) 98%min

Solicitud

HSDD is the most commonly reported form of female sexual dysfunction. HSDD is defined as a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty, and which is not better accounted for by a medical, substance-related , psychiatric (e.g., depression) or other sexual condition. The cause of HSDD is believed to involve a multitude of social, psychological and biological factors and may be attributed to a complex interplay of these factors.

Flibanserin is a novel, nonhormonal drug that has been studied in clinical trials for the treatment of HSDD in premenopausal and postmenopausal women. The application submitted to the FDA is for premenopausal women.

Flibanserin is believed to work on key neurotransmitters, or chemicals, in the brain that affect sexual desire. Más específicamente, it is thought that flibanserin corrects an imbalance of levels of these neurotransmitters by increasing dopamine and norepinephrine (both responsible for sexual excitement) and decreasing serotonin (responsible for sexual inhibition). In clinical studies, flibanserin was evaluated for its ability to increase the frequency of satisfying sexual events, increase the intensity of sexual desire and decrease the associated distress women feel from its loss.

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