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Intelligente Drogen

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  • Pharmazeutische Rohstoffe Memantin HCl CAS 41100-52-1

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    Pharmazeutische Rohstoffe Memantin HCl CAS 41100-52-1

    Product Details:

    Produktname: Memantine HCl
    Synonyme: MEMANTINE HCL;LABOTEST-BB LT00233220;D-145;

    1,3-Dimethyl-5-aminoadamantane hydrochloride;

    1,3-DIMETHYLAMINOADAMANTANE HYDROCHLORIDE;

    1-AMINO-3,5-DIMETHYLADAMANTANE HCL;

    1-AMINO-3,5-DIMETHYLADAMANTANE HYDROCHLORIDE;

    1-AMINO-3,4-DIMETHYLADAMANTANE HYDROCHLORIDE

    FALL: 41100-52-1
    MF: C12H22ClN
    MW: 215.76
    EINECS: 255-219-6
    Schmelzpunkt 292 ° C.
    Chemische Eigenschaften White Crystalline Solid
    Verwendet Used as an antiparkinsonian and antispasmodic
    Produktkategorien Adamantane derivatives;Antispasmodic;Antiparkinsonian;Adamantanes;

    Zwischenprodukte & Feinchemikalien;Arzneimittel;Glutamate receptor;Glutamate;Amine;API;Andere APIs;raw materials

    Chemische Eigenschaften Crystalline Solid
    Verwendung Used as an antiparkinsonian and antispasmodic; Antiparkinsonian;Dopaminergic agonist; Uses Anti Alzheimer’s
    Beschreibung:

    Memantine HCL is an oral medication for the treatment of moderate to severe dementia associated with Alzheimer’s. Memantine HCL’s effects are independent of acetylcholine and acetylcholinesterase.

    Overview of memantine hydrochloride is dementia drugs developed by the German company Merz, is a new type of low, moderate affinity, voltage dependent and non competitive N methyl D aspartate (NMDA) receptor antagonist can noncompetitive NMDA receptor blockade induced by glutamate receptor NMDA, reduce the excessive excitement, prevent cell apoptosis, Gedächtnis verbessern, is a new generation of drugs to improve cognitive function.

    Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer’s disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European. The development of Alzheimer’s disease involves the misfolded mutant proteins such as β-amyloid peptide (, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, Neuropathischer Schmerz, glaucoma, Depression, Huntington-Krankheit, ALS and movement disorders, among other.

    Anwendung:

    It is believed that too much stimulation of nerve cells by glutamate may be responsible for the degeneration of nerves that occurs in some neurological diseases such as Alzheimer’s disease. Glutamate is produced and released by nerve cells in the brain. The released glutamate then travels to nearby nerve cells where it attaches to a receptor on the surface of the cells called the N-methyl-D-aspartate (NMDA) receptor. Memantine HCL blocks this receptor and thereby decreases the effects of glutamate. It is thought that by blocking the NMDA receptor and the effects of glutamate, memantine may protect nerve cells from excess stimulation by glutamate.

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