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  • 99% Efficient Pharmaceutical New Anticancer Drugs Belotecan CAS; 256411-32-2

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    Other Hot-Sale Products (Raw Powder)
    Model Number : 256411-32-2
    Certification : iso9001
    Place of Origin : China
    MOQ : 10G
    Price : 1USD
    Payment Terms : T/T, Western Union, MoneyGram,bitcoin
    Delivery Time : 3-7days
    Packaging Details : 25kg/drum
    name : Belotecan
    cas : 256411-32-2
    Assay : 99%
    MF : C20H27NO3
    MW : 329.4333
    Usage : Anticancer Drugs
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    • Specifications

    99% Efficient Pharmaceutical New Anticancer Drugs Belotecan 25mg CAS; 256411-32-2

    Details

    CAS Number:256411-32-2
    Chemical Formula:C25-H27-N3-O4
    Molecular Weight;433
    Therapeutic Category:Antineoplastic agent
    Chemical Name:(4S)-4-etyl-4-hydroxy-11-[2-(isopropylamino)etyl]-1,12-dihydro-14H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione (WHO)

    Foreign Names
    Belotecanum (Latin)
    Belotecan (German)
    Bélotécan (French)
    Belotecán (Spanish)
    Generic Name
    UNII-27Z82M2G1N (IS)

    Belotecan Description

    Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for Small Cell Lung Cancer and Ovarian Cancer, approved in South Korea under the trade name Camtobell(R), presented in 2 mg vials for injection. The drug is marketed by ChongKunDang Pharmaceuticals since 2003

    Belotecan blocks topoisomerase I with a pIC50 of 6.56,stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.

    Belotecan INTRODUCTION:

    Belotecan (Camtobell, CKD602) is a new camptothecin-derivative antitumor agent that belongs to the topoisomerase inhibitors. The aim of this study was to evaluate the efficacy and safety of belotecan monotherapy as a second-line therapy in patients with relapsed or refractory small cell lung cancer (SCLC).

    Belotecan METHODS:

    Between June 2008 and August 2011, a total of 50 patients with relapsed or refractory SCLC were treated with belotecan 0.5 mg/m for 5 consecutive days, every 3 weeks. We evaluated the overall response rate (ORR), the progression-free survival (PFS), and the overall survival (OS), and toxicity according to sensitivity to initial chemotherapy.

    Belotecan RESULTS:

    The median age was 66 years (range, 43-84 years) and Eastern Cooperative Oncology Group performance was 0 or 1 in 34 patients (68%) and 2 in 16 patients (32%). Twenty patients (40%) had sensitive relapse and 30 patients (60%) had refractory disease. The ORR, PFS, and OS for sensitive patients were 20% (95% confidence interval [CI], 8-40), 2.8 months (95% CI, 0.53-5.06), and 6.5 months (95% CI, 1.58-11.42), respectively. In the refractory group, the ORR, PFS, and OS were 10% (95% CI, 1-21), 1.5 months (95% CI, 1.25-1.75), and 4.0 months (95% CI, 3.40-4.60), respectively. Most commonly reported grade-3 or -4 adverse events included neutropenia (54%), thrombocytopenia (38%), and anemia (32%).

    Belotecan CONCLUSION:

    Belotecan showed modest activity with an acceptable safety profile as a second-line therapy in patients with relapsed or refractory SCLC.

    Competitive advantage:
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